The next step is not exactly for novices, if you do not know the names of files in your system that you should be run on startup. This is where most viruses / spyware / malware will infect your system. They will startup automatically each time you restart your computer and be running all the time. If you are savvy enough you can disable files that are not needed and files that should not be run so that cleaning your systems of threats is much easier. If you are not savvy enough just disable everything and Windows will automatically re-enable anything it deems necessary for it to run. You will need to restart your system to complete this phase of cleaning.